New Class of Inhibitors of Amyloid- Fibril Formation IMPLICATIONS FOR THE MECHANISM OF PATHOGENESIS IN ALZHEIMER’S DISEASE*□S
نویسندگان
چکیده
From the ‡Center for Neurologic Diseases, Brigham and Women’s Hospital and Department of Neurology, Harvard Medical School, Cambridge, Massachusetts 02139, ¶Center for Neurosciences, North Shore/Long Island Jewish Research Institute, Manhasset, New York 11030, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10010, and **Department of Pathology, North Shore University Hospital, Manhasset, New York 11030
منابع مشابه
Preparation and study of the inhibitory effect of nano-niosomes containing essential oil from artemisia absinthium on amyloid fibril formation
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متن کاملNew class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease.
The amyloid hypothesis suggests that the process of amyloid-beta protein (Abeta) fibrillogenesis is responsible for triggering a cascade of physiological events that contribute directly to the initiation and progression of Alzheimer's disease. Consequently, preventing this process might provide a viable therapeutic strategy for slowing and/or preventing the progression of this devastating disea...
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تاریخ انتشار 2002